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KMID : 0043319910140010030
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Archives of Pharmacal Research
1991 Volume.14 No. 1 p.30 ~ p.34
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A Synthetic Study on Cyclic Phosphate Derivatives of Seconucleosides as Potential Antiviral Agents (I): Synthesis of 3’’,5’’-cyclic phosphates of 2’’-substituted secouridines and secoribavirins
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Hong KA
Yang JW/Chun SJ/Ha EY/Kim JH/Chun MW/Chung WK
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Abstract
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The synthetic study of 3’’,5-cyclic phosphates of 2’’-substituted 2’’,3’’-secouridines and 2’’,3’’-secoribavirins toward development of new antiviral agents is described. These cyclic phosphates were synthesized from their respective 4-nitrophenyl 3’’,5’’-cyclic phosphate triesters. These triesters were prepared from the corresponding 2’’-azido and 2’’-bromo 2’’,3’’-seconucleosides.
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